|
Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased lymphocyte apoptosis |
Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Increased circulating antibody level |
Paraproteinemia |
Abnormal bleeding |
Gastrointestinal hemorrhage |
Bruising susceptibility |
Pancytopenia |
Anemia |
Hemolytic anemia |
Neutropenia |
Lymphocytosis |
Monocytosis |
Leukemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Acute myeloid leukemia |
Juvenile myelomonocytic leukemia |
Abnormality of coagulation |
Abnormal platelet function |
Autoimmune thrombocytopenia |
Hematological neoplasm |
Lymphoma |
Lymphoproliferative disorder |
Multiple myeloma |
Abnormality of the spleen |
Splenomegaly |
Hepatosplenomegaly |
| Disease(s) Associated with KRAS | ||||||||||||||||||||||||||||||
| acute lymphoblastic leukemia | ||||||||||||||||||||||||||||||
| acute myeloid leukemia | ||||||||||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome type 4 | ||||||||||||||||||||||||||||||
| Lynch syndrome | ||||||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||||||
| Noonan syndrome | ||||||||||||||||||||||||||||||
| Noonan syndrome 3 | ||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | hematopoietic system phenotype |
spleen vascular congestion |
increased splenocyte proliferation |
abnormal embryonic erythropoiesis |
enlarged spleen |
abnormal hematopoietic system morphology/development |
abnormal definitive hematopoiesis |
abnormal common myeloid progenitor cell morphology |
abnormal erythropoiesis |
abnormal myelopoiesis |
myeloid hyperplasia |
extramedullary hematopoiesis |
anemia |
increased myeloid cell number in bone marrow |
increased granulocyte monocyte progenitor cell number |
abnormal common lymphocyte progenitor cell morphology |
increased basophil cell number |
increased eosinophil cell number |
abnormal erythrocyte morphology |
decreased hematocrit |
decreased hemoglobin content |
decreased mean corpuscular hemoglobin |
anisopoikilocytosis |
polychromatophilia |
increased neutrophil cell number |
increased granulocyte number |
thrombocytopenia |
decreased CD8-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased monocyte cell number |
increased leukocyte cell number |
reticulocytosis |
increased myeloid cell number |
increased hematopoietic stem cell number |
abnormal embryonic erythrocyte morphology |
increased spleen red pulp amount |
abnormal bone marrow cell physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
| Krastm1Mok/Krastm1Mok | * | |||||||||||||||||||||||||||||||||||||
| Krastm1Tyj/Krastm1Tyj | ||||||||||||||||||||||||||||||||||||||
| Krastm4.1Bbd/Krastm4.1Bbd | ||||||||||||||||||||||||||||||||||||||
| Krastm4.1Bbd/Kras+ | ||||||||||||||||||||||||||||||||||||||
| Krastm1.1Khai/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Meox2tm1(cre)Sor/Meox2+ (conditional) |
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| Krastm4Tyj/Kras+ (conditional) | ||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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